Mechanism of regulation of plant innate immunity G protein found in Genetics and Developmental Biology, etc: eLIFE
Plant immune receptors can feel a variety of pathogenic molecular patterns, and by cytoplasmic kinase receptor activation of downstream BIK1 immune response. Recent studies have found that freezer atypical Gα protein XLG2 / 3, Gβ protein AGB1 and Gγ protein AGG1 / 2 formation of a heterologous G protein trimer involved in the regulation of immune receptors FLS2 mediated immune response, but the mechanism is unknown.
Institute of Genetics and Developmental Biology Research Group Zhou Jian, China and Canada Zhangyue Lin Study Group co-found a heterologous G protein trimer can FLS2-BIK1 receptor complex interactions. Before activating the immune response, G protein is a protein BIK1 26S proteasome-mediated degradation to enhance the stability of BIK1, Labratory freezer properly adjusted for activation of the immune response; FLS2 after being activated, can quickly BIK1 protein phosphorylation of the N-terminal protein XLG2, phosphorylated XLG2 AGB1 and dissociation, and then by adjusting RbohD activity for inducing reactive oxygen outbreak.
These results suggest that plant G protein-coupled immune receptor complex phase, before and after the activation of the immune activation of the immune response signals regulated by two different mechanisms, revealed the G protein-coupled receptors and the similarities and differences in the way animals and plants . The study results were published online April 4 in eLIFE. Dr. Liang Xiang Xiu Min and Zhou Jian Canadian University Study Group of British Columbia (UBC) Dr. Ding Pingtao as co-first author. The study was funded by the National Natural Science Foundation of China, Ministry of Science, "973" project and the Chinese Academy of Sciences of the pilot projects.