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EID: Advances evolution and spread of swine streptococcus virulence Pingyou Jun Zhejiang University professor published
2016-04-25 15:19:51
       April 5, 2016, the international academic journal "EID" published online Basic Medical freezer College of Zhejiang University Professor,Center for Infection and Immunity Pingyou Jun reveal suis (Streptococcus suis) the emerging / zoonotic pathogens burst virulence molecular evolution and progress in terms of spread. Research paper entitled "Loss of 89K Pathogenicity Island in Epidemic Streptococcus suis, China".
 
 
      Streptococcus suis is not only a major swine pathogen, but also an emerging zoonotic pathogen. Retrospective analysis, outbreaks in China have been two cases of Streptococcus suis infection epidemic crowd, which caused serious concerns in public health, but also the challenge of the "swine streptococcus causes only sporadic opportunistic infections," the traditional view. In view of the Streptococcus suis type II (SS2) the performance of the highly invasive and virulent, a number of domestic research group for the pathogen carried out extensive research and fruitful. Professor Feng in its early stages as a major doctoral study reveals the participation of members from the pigs caused by Streptococcus "streptococcal shock syndrome (STSS)" This new type of disease, but also identified a Chinese virulent strain specific to 89K pathogenicity islands. Professor Feng group isolated from the Guangdong region of humanized SS2 (2008-2015) epidemiological studies carried out molecular systems. Microbiology and molecular biology experiments to understand these humanized bacterial strains isolated identity, namely Streptococcus suis. Pulsed field gel electrophoresis (PFGE) and SAO nuclear protein analysis provides evidence that the heterogeneity of these clinical isolates. What was most surprising, previously found unique 89K island of the lost virulence in these SS2 epidemic strain. The findings suggest that "the nuclear genome of S. suis heterogeneous populations are evolving to adapt to the environment source / selective pressure for some unknown host" this possibility.